Geralt of Rivia is a Witcher - a highly skilled monster hunter who uses a combination of magic and blade to subdue the monsters roaming the lands. Awakening with no memory of who he is, Geralt finds himself in the company of other Witchers in the castle of Kaer Morhen, which comes under attack by a group of bandits known as the Salamandra. The bandits escape with the mutagens used by Witchers to genetically enhance themselves, and now it's up to Geralt to track them down.

Players will take control of Geralt as he travels to Vizima, the capital city of Temeria to uncover the Salamandra conspiracy and stop its evil plans.