Resident Evil: Revelations 2 is set after the events of Resident Evil 5 and before the events of Resident Evil 6. The game is divided into 5 episodes, each episode split into two, and follows two protagonists, Claire Redfield and Barry Burton, and two sidekicks, Moira and Natalia.

Only one of the protagonists can use a gun while the other one has to use weapons like bricks and crowbars, leaving them more vulnerable to attacks. The game supports co-op action also.