Despite the death of Zakhaev, the Ultranationalists gained the upper hand in Russia. After a terrorist attack in Moscow frames the CIA, Russia begins a full-fledged invasion of the United States, and it is now up to the newly formed Task Force 141 to find the real perpetrator behind the attack, the sadistic Vladimir Makarov.

In this stylish, globe-trotting shooter, players are confronted with a monumental conflict as they fight across several fronts in a war with no borders - and no rules. From the favelas of Rio de Janeiro to the harsh desert of Afghanistan, players must find Makarov and bring and end to the disastrous conflict sweeping the world.